My Blog Posts

2019 3/Jan

Today’s medical biochemistry note is about Coenzyme Q10 and idiopathic male infertility. Worldwide 15% of reproductive-age couples suffer from infertility, and male infertility contributes to almost half of infertility cases [1-3]. Male infertility can be attributed to multifactorial heterogeneous conditions, including varicocele, cryptorchidism, hypogonadism, infection, systemic diseases, testicular cancer, genetic abnormalities, and oxidative stress-induced male […]

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2018 10/Jul

Hemoglobin (Heme + Globin) is a heterotetramer composed of four polypeptide subunits (2 α and 2 β), each with a prosthetic heme group plus a globin chain. The heme group is formed of a heterocyclic ring, known as a porphyrin which contains an iron (Fe) atom in its center. Usually, the Fe is in the […]

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2018 20/May

Disseminated intravascular coagulation (DIC) is a syndrome resulting from the inappropriate activation of blood coagulation and formation of microvascular thrombi. During the process, consumption of platelets and coagulation factor occur. In some cases, activation of the fibrinolytic pathway may cause severe bleeding. If sufficiently severe, DIC can produce multiple organ dysfunction syndrome (MODS). Commonly patients with DIC have alterations in […]

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2018 21/Feb

Anemia is strictly defined as a decrease in red blood cell (RBC) mass or blood hemoglobin concentration. The prevalence of anemia in population studies of healthy, nonpregnant people depends on the hemoglobin (Hb) levels chosen for the lower limit of normal values. The World Health Organization (WHO) anemia definition is Hb levels <12.0 g/dL in women and […]

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2018 16/Feb

The cell is the basic unit with cell membrane that contains the fundamental molecules of life. All living things are composed of cells, and an organelle is a specialized subunit within a cell that has a specific function. Individual organelles are usually separately enclosed within their own lipid bilayers. Cilia and Kartagener syndrome It’s a variant of […]

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2018 25/Jan

Celiac disease or gluten-sensitive enteropathy is an autoimmune disorder, which is frequently associated with the follow autoimmune conditions: Type 1 Diabetes Mellitus Multiple Sclerosis (MS) Hashimoto’s thyroiditis Autoimmune hepatitis Addison disease Arthritis Sjögren’s syndrome Idiopathic dilated cardiomyopathy IgA nephropathy Thyroid disease (Hashimoto’s thyroiditis) and Type 1 Diabetes are the most common disorders associated with celiac […]

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2018 25/Jan

Apoptosis is a specialized form of programmed cell death, characterized by lack of inflammatory response. It is an active process regulated by proteins that often affects only single cells or small groups of cells. So, what is the biochemical pathway leading to apoptosis? Activation of caspases cascade. Caspase activation is the crucial step because caspases […]

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2018 18/Jan

Amyloidosis is a group of the conditions characterized by extracellular and intracellular deposition of an insoluble protein called amyloid fibrils. Deposits of abnormal amyloid alter the normal function of tissues. The diagnosis requires tissue biopsy (needs to be congo-red positive) usually take from the rectum or abdominal fat pads. What is Amyloid? Around 90 percent […]

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2018 17/Jan

Definition: severe elevation in WBC (> 50,000 cells/mm³) caused by reactive causes outside the bone marrow. It’s a normal physiologic response to infection or stress. The diagnostic workup consists of the exclusion of chronic myelogenous leukemia (CML) and chronic neutrophilic leukemia (CNL) and the detection of an underlying cause. The diagnosis characteristics are marked mature […]

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2018 15/Jan

The differences between RBBB and LBBB in ECG are more simple than you imagine!. Just follow two simple steps: QRS duration greater than or equal to 120 ms in adults (>0.12 sec or >3 small boxes), greater than 100 ms in children 4 to 16 years of age, and greater than 90 ms in children […]

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