My Blog Posts

2019 3/Jan

Today’s medical biochemistry note is about Coenzyme Q10 and idiopathic male infertility. Worldwide 15% of reproductive-age couples suffer from infertility, and male infertility contributes to almost half of infertility cases [1-3]. Male infertility can be attributed to multifactorial heterogeneous conditions, including varicocele, cryptorchidism, hypogonadism, infection, systemic diseases, testicular cancer, genetic abnormalities, and oxidative stress-induced male […]

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2018 10/Jul

Hemoglobin (Heme + Globin) is a heterotetramer composed of four polypeptide subunits (2 α and 2 β), each with a prosthetic heme group plus a globin chain. The heme group is formed of a heterocyclic ring, known as a porphyrin which contains an iron (Fe) atom in its center. Usually, the Fe is in the […]

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2018 21/Feb

Anemia is strictly defined as a decrease in red blood cell (RBC) mass or blood hemoglobin concentration. The prevalence of anemia in population studies of healthy, nonpregnant people depends on the hemoglobin (Hb) levels chosen for the lower limit of normal values. The World Health Organization (WHO) anemia definition is Hb levels <12.0 g/dL in women and […]

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2018 25/Jan

Apoptosis is a specialized form of programmed cell death, characterized by lack of inflammatory response. It is an active process regulated by proteins that often affects only single cells or small groups of cells. So, what is the biochemical pathway leading to apoptosis? Activation of caspases cascade. Caspase activation is the crucial step because caspases […]

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2018 18/Jan

Amyloidosis is a group of the conditions characterized by extracellular and intracellular deposition of an insoluble protein called amyloid fibrils. Deposits of abnormal amyloid alter the normal function of tissues. The diagnosis requires tissue biopsy (needs to be congo-red positive) usually take from the rectum or abdominal fat pads. What is Amyloid? Around 90 percent […]

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2018 5/Jan

Pancreas Divisum Pancreas divisum results from a failure of ventral and dorsal bud fusion. The ventral (Wirsung) duct drains only the ventral pancreatic anlage, whereas the majority of the gland empties into the minor papilla through the dorsal (Santorini) duct. It is the most common congenital anomaly, occurring in 4%–14% of the population, as evidenced […]

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2018 5/Jan

Pancreatic cancer is responsible for 7% of all cancer-related deaths, and it is now the third leading cause of cancer-related deaths in both women and men. It’s considered a highly lethal disease, for which the relative 1-year survival rate for pancreatic cancer is only 28%. Patients often present with advanced disease, and at the time […]

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